GDNF, CDNF and MANF have divergent effects on nigrostriatal dopamine neurochemistry in rats
نویسندگان
چکیده
منابع مشابه
Neurotrophic factors and their receptors
........................................................................................................12 1. LITERATURE REVIEW...............................................................................14 1.1 NEUROTROPHIC FACTORS ....................................................................................14 1.2 THE GDNF FAMILY OF NEUROTROPHIC FACTORS ...................................
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1. Review of the literature .............................................................................................1 1.1. Neurotrophic factors: The concept ........................................................................1 1.2. Neurotrophic factors for midbrain dopaminergic neurons ....................................3 1.2.1. Neurotrophins..............................................
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Given the established importance of glial cell line-derived neurotrophic factor (GDNF) in maintaining dopaminergic neurotransmitter systems, the nigrostriatal system and associated behaviors of mice with genetic reduction of its high-affinity receptor, GDNF receptor (GFR)alpha-1 (GFRalpha-1(+/-)), were compared with wild-type controls. Motor activity and the stimulatory effects of a dopamine (D...
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Mammalian MANF and CDNF proteins are evolutionarily conserved neurotrophic factors that can protect and repair mammalian dopaminergic neurons in vivo. In Drosophila, the sole MANF protein (DmManf) is needed for the maintenance of dopaminergic neurites and dopamine levels. Although both secreted and intracellular roles for MANF and CDNF have been demonstrated, very little is known about the mole...
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ژورنال
عنوان ژورنال: Proceedings for Annual Meeting of The Japanese Pharmacological Society
سال: 2018
ISSN: 2435-4953
DOI: 10.1254/jpssuppl.wcp2018.0_po2-1-52